Syntegon ALF 5000 and FLC 3000 Vial Liquid Filling Machines

Published specifications

These are the manufacturer's published values. Confirm them for your product and configuration before ordering.

Packaging format

bottle (manufacturer stated)

Product to pack

liquid (manufacturer stated)

Maximum rated output

600 packs/min (manufacturer stated)

ALF 5000 and FLC 3000 in brief

The ALF 5000 and FLC 3000 are Syntegon's named liquid fillers for vials. Each is listed at 600 containers per minute, with up to 12 filling heads and a choice of RABS or isolator. The ALF 5000 handles vials of 2–500 ml plus ampoules of 1–30 ml and checks the fill of every vial. The FLC 3000 is a vial machine for 2–500 ml with statistical fill checking and a modular layout. Pick ALF when ampoules are part of the job; pick FLC for vial-only work.

Who supplies the machine

Syntegon publishes the model comparison on its global vial-filling page. [1] The Hangzhou company lists vial, ampoule, pre-filled syringe and capsule filling, together with isolator, inspection, qualification, validation and service work. [2]

Because the comparison comes from the group page, ask who will contract, build, integrate, test and support your line. Ask too whether the machine would come from Hangzhou stock or from another group site, and whether one contract covers it all.

Decide the scope first: vials only, vials and ampoules, or a line that feeds freeze-drying. Send container drawings and dosage requirements before discussing how many filling heads you need. The pumping system, barrier set-up and batch strategy follow from your product and plan.

Model comparison

Syntegon's comparison, read on 11 October 2026, gives the figures below. All of them vary with configuration. [1]

Swipe or scroll the table to compare all columns.

The 600 figure is a top rate. Your rate will depend on fill volume, liquid, head count and inspection set-up. "Up to 12" is a maximum too, so ask how many heads the offer includes. Have Syntegon tie output, format, dosing system and in-process control to one quoted configuration.

The table points to a first split. Look at ALF when you must run ampoules alongside vials. Look at FLC for vial work and its layout options. If ampoules are in scope, plan the carton stage as well: Beili's ampoule cartoner takes injections already placed in trays or blisters, so you need a tray-loading step between filler and cartoner. Settle technical fit and the knock-on effects on the whole line before you compare prices.

In-process control and inspection

Syntegon's comparison lists 100% in-process control for vials on the ALF entry and statistical IPC on the FLC entry. Ask what is measured, at which point, what happens to a failing container, and whether the system stores each result or only sampled results. Keep the quoted wording, statistical or 100%, exactly as offered in your specification. [1]

Fill control, visual inspection and container-closure integrity testing each answer a separate question. Syntegon's page covers particle and cosmetic inspection, leak detection and empty-vial checks as parts of a line. Ask which of these come with the base filler and which appear in your quotation as extra stations. [1]

Swipe or scroll the table to compare all columns.

Your technical and quality teams should work through these questions with Syntegon and sign off the inspection protocol themselves.

The full vial line

Syntegon describes a line that runs from formulation and pure media through vial pretreatment, filling and closing, freeze-drying, barriers, inspection and sterilization. Choose the stages your process needs. Each one is quoted as its own scope and price item. [1]

Draw the boundary for the proposal. Show the incoming vial condition, the product feed point, stopper and cap supply, the filling and closing stages, any transfer to freeze-drying, and the state of containers passed to inspection. Mark each supplier's scope and your utilities and building connections. A drawing like this keeps a mechanically complete filler from being mistaken for a commissioned line.

Syntegon offers several filling methods: rotary-valve piston, time-pressure, peristaltic, mass-flow and rolling-diaphragm pumps, with multi-use or single-use fluid paths. Ask which method Syntegon proposes for your formulation and why. Ask for trial results on representative product or an agreed test medium. [1]

Vial volume alone is a weak basis for choosing. Discuss dose range, viscosity, foaming, product sensitivity, batch size, the product-contact path and changeover needs. Ask Syntegon to state filling accuracy, allowable product hold time and cleaning results for your formulation as written answers in the offer.

Barrier and validation scope

Both machines list RABS or isolator integration. Zhongya's DABL bottle line follows another aseptic route: it sterilizes plastic bottles and caps with dry H2O2 for liquid foods, so its barrier questions differ from a vial filler's. Syntegon's page uses Annex 1 and GMP wording and describes CIP/SIP capability and optional filter-test arrangements. [1]

Request the exact barrier arrangement offered, the operator-access concept, the intervention scope, cleaning and decontamination duties and the interface documents. Your qualified quality and engineering staff should set the requirements, validation deliverables and process setpoints for your product.

The Hangzhou page lists qualification and validation among its services. Confirm the contracted services, documents, languages, acceptance milestones and who is responsible for each site-specific qualification task. [2]

Output, batches and changeover

On short batches with frequent changes, preparation, line clearance and changeover often limit output more than the running speed does. Ask for separate times for format change, product-path change, cleaning and restart to accepted production. Syntegon describes fast tool-free changeover on the ALF and a few-part modular design on the FLC, without one changeover time for all formats. [1]

As a rough planning figure, 600 containers/min for 60 minutes without a stop comes to 36,000 containers through the machine. Released doses will be fewer. Accepted output depends on how units are counted, operating time, rejects and downstream limits.

Compare offers on the same batch plan and the same counting rule. Record units accepted on the first pass separately from units recovered after rework, so repeated first-time rejects stay visible. Ask how the trial will log interventions, stoppages and the agreed inspection scope.

Confirm before ordering

Ask Syntegon to put these in writing: project price, lead time, service response in your country, filling accuracy for your liquid, utility consumption, full installation footprint, software deliverables, the change-part list and the manufacturing site for the configuration offered. Syntegon's customer case studies describe particular projects. Ask for references with a product and container close to yours, and base your expectations on the configuration proposal and acceptance agreement.

Inquiry checklist

Buyer questions

Sources and verification

[1] Syntegon official vial filling machines portfolio
Read 11 October 2026. ALF 5000 and FLC 3000 comparison, filling methods and line-integration options.

[2] Syntegon official Hangzhou location profile
Read 11 October 2026. Hangzhou portfolio and service categories.